CFTR recombinant monoclonal antibody, clone CFTR/1775R
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CFTR.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to amino acids 258-385 of human CFTR.
Theoretical MW (kDa)
165-170
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG, kappa
Recommend Usage
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human pancreas with CFTR recombinant monoclonal antibody, clone CFTR/1775R (Cat # RAB00317).Immunofluorescence
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Gene Info — CFTR
Entrez GeneID
1080Protein Accession#
P13569Gene Name
CFTR
Gene Alias
ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1
Gene Description
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq
Other Designations
ATP-binding cassette sub-family C, member 7|cystic fibrosis transmembrane conductance regulator
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Interactome
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Pathway
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Disease
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Publication Reference
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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.
J R Riordan, J M Rommens, B Kerem, N Alon, R Rozmahel, Z Grzelczak, J Zielenski, S Lok, N Plavsic, J L Chou, et al.
Science 1989 Sep; 45(4922):1066.
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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.
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