Recombinant mouse monoclonal antibody raised against human TNFRSF8.
Original antibody is raised against recombinant protein corresponding to full length human TNFRSF8.
Theoretical MW (kDa):
Recognizes a single chain glycoprotein of 105/120kDa, identified as TNFRSF8.
Protein A/G purification
Flow Cytometry (0.5-1 ug/million cells) Immunofluorescence (1-2 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
In 10 mM PBS.
Store at -20°C. Aliquot to avoid repeated freezing and thawing.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq