POMC recombinant monoclonal antibody, clone r57
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Specification
Product Description
Mouse recombinant monoclonal antibody raised against human POMC.
Antibody Species
Mouse
Immunogen
N-terminal fragment of human POMC conjugated to KLH.
Theoretical MW (kDa)
~5, ~30
Reactivity
Human
Specificity
This antibody is specific to synacthen (amino acids 1-24 of POMC); does not react with CLIP (amino acids 17-39 of POMC).
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA and 0.05% azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human pituitary gland with POMC recombinant monoclonal antibody, clone r57 (Cat # RAB00309).Immunofluorescence
Flow Cytometry
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Gene Info — POMC
Entrez GeneID
5443Protein Accession#
P01189Gene Name
POMC
Gene Alias
ACTH, CLIP, LPH, MSH, NPP, POC
Gene Description
proopiomelanocortin
Gene Ontology
HyperlinkGene Summary
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq
Other Designations
OTTHUMP00000119991|adrenocorticotropic hormone|adrenocorticotropin|alpha-MSH|alpha-melanocyte-stimulating hormone|beta-LPH|beta-MSH|beta-endorphin|beta-melanocyte-stimulating hormone|corticotropin-like intermediary peptide|gamma-LPH|gamma-MSH|lipotropin b
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Interactome
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Pathway
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Disease
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Publication Reference
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Coexpression of galanin and adrenocorticotropic hormone in human pituitary and pituitary adenomas.
Hsu DW, Hooi SC, Hedley-Whyte ET, Strauss RM, Kaplan LM.
The American Journal of Pathology 1991 Apr; 138(4):897.
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Coexpression of galanin and adrenocorticotropic hormone in human pituitary and pituitary adenomas.
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