MUC1 recombinant monoclonal antibody, clone rMUC1/960
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Specification
Product Description
Mouse recombinant monoclonal antibody raised against human MUC1.
Antibody Species
Mouse
Immunogen
Human milk-fat globule membranes (HMFGM)
Theoretical MW (kDa)
265-400
Reactivity
Human
Specificity
This antibody reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia.
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human ovarian carcinoma with MUC1 recombinant monoclonal antibody, clone rMUC1/960 (Cat # RAB00308).Immunofluorescence
Flow Cytometry
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Gene Info — MUC1
Entrez GeneID
4582Protein Accession#
P15941Gene Name
MUC1
Gene Alias
CD227, EMA, H23AG, MAM6, PEM, PEMT, PUM
Gene Description
mucin 1, cell surface associated
Omim ID
158340Gene Ontology
HyperlinkGene Summary
This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. [provided by RefSeq
Other Designations
DF3 antigen|H23 antigen|MUC-1/SEC|MUC-1/X|MUC1/ZD|OTTHUMP00000033787|OTTHUMP00000033790|OTTHUMP00000033795|breast carcinoma-associated antigen DF3|episialin|mucin 1|mucin 1, transmembrane|peanut-reactive urinary mucin|polymorphic epithelial mucin|tumor as
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Interactome
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Disease
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Publication Reference
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Selective secretion and replenishment of discrete mucin glycoforms from intestinal goblet cells.
Stanley CM, Phillips TE.
The American Journal of Physiology 1999 Jul; 277(1):G191.
Application:ICC, Human, HT29–18N2 goblet cells.
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Selective secretion and replenishment of discrete mucin glycoforms from intestinal goblet cells.
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