KRT7 recombinant monoclonal antibody, clone rOV-TL12/30
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Specification
Product Description
Mouse recombinant monoclonal antibody raised against human KRT7.
Antibody Species
Mouse
Immunogen
OTN 11 ovarian carcinoma cell line
Theoretical MW (kDa)
55
Reactivity
Human
Specificity
This antibody is highly specific to KRT7 and shows no cross-reaction with other IFPs (intermediate filament proteins).
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human endometrial carcinoma with KRT7 recombinant monoclonal antibody, clone rOV-TL12/30 (Cat # RAB00302).Immunofluorescence
Flow Cytometry
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Gene Info — KRT7
Entrez GeneID
3855Protein Accession#
P08729Gene Name
KRT7
Gene Alias
CK7, K2C7, K7, MGC129731, MGC3625, SCL
Gene Description
keratin 7
Omim ID
148059Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq
Other Designations
cytokeratin 7|keratin, 55K type II cytoskeletal|keratin, simple epithelial type I, K7|keratin, type II cytoskeletal 7|sarcolectin|type II mesothelial keratin K7
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Interactome
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Publication Reference
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Use of monoclonal antibodies to keratin 7 in the differential diagnosis of adenocarcinomas.
Ramaekers F, van Niekerk C, Poels L, Schaafsma E, Huijsmans A, Robben H, Schaart G, Vooijs P.
The American Journal of Pathology 1990 Mar; 136(3):641.
Application:IHC, WB-Ti, Human, Malignant epithelial tissues.
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Use of monoclonal antibodies to keratin 7 in the differential diagnosis of adenocarcinomas.
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