CD44v4 recombinant monoclonal antibody, clone CD44v4/1700R
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cervical squamous cell carcinoma with CD44v4 recombinant monoclonal antibody, clone CD44v4/1700R (Cat # RAB00293).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CD44v4.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to the v4 domain of human CD44.
Reactivity
Human
Specificity
Recognizes an epitope encoded by exon v4 on the variant portion of human CD44.
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA and 0.05% azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cervical squamous cell carcinoma with CD44v4 recombinant monoclonal antibody, clone CD44v4/1700R (Cat # RAB00293).Immunofluorescence
Flow Cytometry
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Gene Info — CD44
Entrez GeneID
960Protein Accession#
P16070Gene Name
CD44
Gene Alias
CDW44, CSPG8, ECMR-III, HCELL, IN, LHR, MC56, MDU2, MDU3, MGC10468, MIC4, MUTCH-I, Pgp1
Gene Description
CD44 molecule (Indian blood group)
Omim ID
107269Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq
Other Designations
CD44 antigen|CD44 antigen (homing function and Indian blood group system)|CDW44 antigen|GP90 lymphocyte homing/adhesion receptor|Hermes antigen|antigen gp90 homing receptor|cell adhesion molecule|cell surface glycoprotein CD44|chondroitin sulfate proteogl
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Interactome
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Pathway
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Disease
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Publication Reference
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The association of co-expression of CD44v4/MMP-9 with different nodal status in high-grade breast carcinoma patients.
Thanakit V, Sampatanukul P, Ruangvejvorachai P, Keelawat S .
Journal of the Medical Association of Thailand 2005 Sep; 88 Suppl 4:S30.
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Expression of CD44 variant isoforms and association to the benign form of endocrine pancreatic tumours.
Imam H, Eriksson B, Öberg K .
Annals of Oncology 2000 Mar; 11(3):295.
Application：IHC, Human, Human pancreas, Human pancreatic tumours.
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The association of co-expression of CD44v4/MMP-9 with different nodal status in high-grade breast carcinoma patients.
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