ABCB1 recombinant monoclonal antibody, clone MRK16
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human ABCB1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against drug resistant K-562 cells.
Reactivity
Human
Specificity
This antibody recognizes a discontinuous extracellular epitope on ABCB1.
Form
Liquid
Purification
Protein A affinity purification
Isotype
IgG, kappa
Recommend Usage
Flow Cytometry (1 ug/mL)
Immunofluorescence
Immunoprecipitation (10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.02% Proclin 300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunofluorescence
Immunoprecipitation
Flow Cytometry
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Gene Info — ABCB1
Entrez GeneID
5243Protein Accession#
P08183Gene Name
ABCB1
Gene Alias
ABC20, CD243, CLCS, GP170, MDR1, MGC163296, P-GP, PGY1
Gene Description
ATP-binding cassette, sub-family B (MDR/TAP), member 1
Omim ID
171050Gene Ontology
HyperlinkGene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq
Other Designations
ATP-binding cassette, subfamily B, member 1|P glycoprotein 1|P-glycoprotein 1|colchicin sensitivity|doxorubicin resistance|multidrug resistance 1|multidrug resistance protein 1
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