ITGAL humanized monoclonal antibody, clone hu1124 (Efalizumab)
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Specification
Product Description
Humanized recombinant monoclonal antibody raised against human ITGAL.
Antibody Species
Human
Immunogen
Original antibody is raised against human ITGAL.
Reactivity
Human
Specificity
This antibody binds to human ITGAL.
Form
Liquid
Purification
Protein A affinity purification
Isotype
Human IgG1, kappa
Recommend Usage
Blocking
Flow Cytometry (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.02% Proclin 300)
Storage Instruction
Store at 4°C for up to 3 months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
Efalizumab binds to the LFA-1 alpha I domain blocking the ICAM-1 binding site via steric hindrance.
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Applications
Blocking
Flow Cytometry
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Gene Info — ITGAL
Entrez GeneID
3683Protein Accession#
P20701Gene Name
ITGAL
Gene Alias
CD11A, LFA-1, LFA1A
Gene Description
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Omim ID
153370Gene Ontology
HyperlinkGene Summary
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
LFA-1 alpha|antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide|integrin alpha L|integrin gene promoter|lymphocyte function-associated antigen 1
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