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Last updated: 2022/7/3

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IL2RA recombinant monoclonal antibody, clone Basiliximab 

  • Catalog # : RAB00048
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  • Specification
  • Product Description:
  • Recombinant human monoclonal antibody raised against human IL2RA.
  • Reactivity:
  • Human
  • Specificity:
  • Basiliximab recognises the human IL-2R and binds to the epitope (116)ERIYHFV(122) within the extracellular domain of the CD25 subunit- binding is abolished when 2 or more residues within the epitope are mutated. This epitope overlaps with the interaction site of CD25 and IL-2. CD25 is found in the high-affinity IL-2R (alpha beta gamma c)- T cells only express CD25 upon activation. IL-2 binding to IL-2R on T cells modulates proliferation and differentiation.
  • Form:
  • Liquid
  • Preparation Method:
  • Basiliximab was prepared by immunizing BALB/c mice with CTC 16 cells.
  • Purification:
  • Protein A affinity purification
  • Isotype:
  • Human IgG1, kappa
  • Recommend Usage:
  • Blocking
    Flow Cytometry (1 ug/mL)
    Immunohistochemistry (5 ug/mL)
    Western Blot (1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (0.02% Proclin 300).
  • Storage Instruction:
  • Store at 4°C for up to 3 months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This is a chimeric antibody created for improved compatibility with existing reagents, assays and techniques.
  • Antibody Species:
  • Human
  • Applications
  • Western Blot
  • Immunohistochemistry
  • Immunofluorescence
  • Blocking
  • Flow Cytometry
  • Application Image
  • Western Blot
  • Immunohistochemistry
  • Immunofluorescence
  • Blocking
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3559
  • Gene Name:
  • IL2RA
  • Gene Alias:
  • Gene Description:
  • interleukin 2 receptor, alpha
  • Gene Summary:
  • The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. [provided by RefSeq
  • Other Designations:
  • Interleukin-2 receptor,OTTHUMP00000019030,OTTHUMP00000044870,interleukin 2 receptor, alpha chain
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