IL2RA humanized monoclonal antibody, clone Basiliximab
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Specification
Product Description
Humanized recombinant monoclonal antibody raised against human IL2RA.
Antibody Species
Human
Reactivity
Human
Specificity
Basiliximab recognises the human IL-2R and binds to the epitope (116)ERIYHFV(122) within the extracellular domain of the CD25 subunit- binding is abolished when 2 or more residues within the epitope are mutated. This epitope overlaps with the interaction site of CD25 and IL-2. CD25 is found in the high-affinity IL-2R (alpha beta gamma c)- T cells only express CD25 upon activation. IL-2 binding to IL-2R on T cells modulates proliferation and differentiation.
Form
Liquid
Preparation Method
Basiliximab was prepared by immunizing BALB/c mice with CTC 16 cells.
Purification
Protein A affinity purification
Isotype
Human IgG1, kappa
Recommend Usage
Blocking
Flow Cytometry (1 ug/mL)
Immunofluorescence
Immunohistochemistry (5 ug/mL)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.02% Proclin 300)
Storage Instruction
Store at 4°C for up to 3 months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This is a chimeric antibody created for improved compatibility with existing reagents, assays and techniques.
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Applications
Western Blot
Immunohistochemistry
Immunofluorescence
Blocking
Flow Cytometry
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Gene Info — IL2RA
Entrez GeneID
3559Protein Accession#
P01589Gene Name
IL2RA
Gene Alias
CD25, IDDM10, IL2R, TCGFR
Gene Description
interleukin 2 receptor, alpha
Gene Ontology
HyperlinkGene Summary
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. [provided by RefSeq
Other Designations
Interleukin-2 receptor|OTTHUMP00000019030|OTTHUMP00000044870|interleukin 2 receptor, alpha chain
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