CD40LG humanized monoclonal antibody, clone hu5c8 (Ruplizumab)
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Specification
Product Description
Humanized recombinant monoclonal antibody raised against human CD40LG.
Antibody Species
Human
Immunogen
Original antibody is raised against native purified human CD40LG.
Reactivity
Human
Specificity
This antibody binds to CD40LG with an IC50 of 0.845 ug/mL.
Form
Liquid
Purification
Protein A affinity purification
Isotype
Human IgG1, kappa
Recommend Usage
Blocking
Flow Cytometry (1 ug/mL)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.02% Proclin 300)
Storage Instruction
Store at 4°C for up to 3 months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Blocking
Flow Cytometry
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Gene Info — CD40LG
Entrez GeneID
959Protein Accession#
P29965Gene Name
CD40LG
Gene Alias
CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L
Gene Description
CD40 ligand
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq
Other Designations
CD40 antigen ligand|OTTHUMP00000024130|T-B cell-activating molecule|TNF-related activation protein|tumor necrosis factor (ligand) superfamily member 5
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