Western blot using TRIM29 polyclonal antibody (Cat # PAB9976) shows reactivity by dot blot with acetylated and non-acetylated forms of the immunizing peptide. This antibody is predicted to recognize both acetylated (TRIM29) and non-acetylated forms of TRIM29 protein. Personal communication, Z. Yuan, H Lee Moffitt Cancer Center and Research Institute.
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq
ataxia-telangiectasia group D-associated protein,tripartite motif protein TRIM29