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Western Blot (Transfected lysate)

Western blot using TP53BP2 polyclonal antibody (Cat # PAB9975) to detect over-expressed TP53BP2 in MCF-7 cells (Lane 2, arrowhead).
Lane 1 is a non-transfected control.
Lane 3 is MCF-7 cells over-expressing PPP1R13B.
Cell extracts were electrophoresed and transferred to nitrocellulose.
The membrane was probed with the primary antibody at a 1 : 1,000 dilution.
The identity of the lower MW band at approximately 40 KDa is unknown.
Personal Communication, H. Yang, Univ. Oklahoma, Oklahoma City, OK.

Immunohistochemistry

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

7159

Protein Accession#

NP_001026855;Q13625

Gene Name

TP53BP2

Gene Alias

53BP2, ASPP2, BBP, PPP1R13A, p53BP2

Gene Description

tumor protein p53 binding protein, 2

Omim ID

602143

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

BCL2-binding protein|NY-REN-51 antigen|apoptosis-stimulating protein of p53, 2|tumor suppressor p53-binding protein 2