ALOX5AP polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot using ALOX5AP polyclonal antibody on human kidney cell lysate.
Lysate used at 15 ug/lane, antibody used at 5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ALOX5AP.
Immunogen
A synthetic peptide corresponding to human ALOX5AP.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot using ALOX5AP polyclonal antibody on human kidney cell lysate.
Lysate used at 15 ug/lane, antibody used at 5 ug/mL . -
Gene Info — ALOX5AP
Entrez GeneID
241Gene Name
ALOX5AP
Gene Alias
FLAP
Gene Description
arachidonate 5-lipoxygenase-activating protein
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. [provided by RefSeq
Other Designations
MK-886-binding protein|OTTHUMP00000018204|five-lipoxygenase activating protein
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Interactome
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Disease
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Publication Reference
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The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.
Helgadottir A, Manolescu A, Thorleifsson G, Gretarsdottir S, Jonsdottir H, Thorsteinsdottir U, Samani NJ, Gudmundsson G, Grant SF, Thorgeirsson G, Sveinbjornsdottir S, Valdimarsson EM, Matthiasson SE, Johannsson H, Gudmundsdottir O, Gurney ME, Sainz J, Thorhallsdottir M, Andresdottir M, Frigge ML, Topol EJ, Kong A, Gudnason V, Hakonarson H, Gulcher JR, Stefansson K.
Nature Genetics 2004 Mar; 36(3):233.
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Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis.
Dixon RA, Diehl RE, Opas E, Rands E, Vickers PJ, Evans JF, Gillard JW, Miller DK.
Nature 1990 Jan; 343(6255):282.
Application：WB-Tr, Human, Osteosarcoma 143 cells.
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The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.
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