SMPD1 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SMPD1.
Immunogen
A synthetic peptide corresponding to human SMPD1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — SMPD1
Entrez GeneID
6609Gene Name
SMPD1
Gene Alias
ASM, NPD
Gene Description
sphingomyelin phosphodiesterase 1, acid lysosomal
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
acid sphingomyelinase
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Human acid sphingomyelinase.
Lansmann S, Schuette CG, Bartelsen O, Hoernschemeyer J, Linke T, Weisgerber J, Sandhoff K.
European Journal of Biochemistry 2003 Mar; 270(6):1076.
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Functional characterization of the N-glycosylation sites of human acid sphingomyelinase by site-directed mutagenesis.
Ferlinz K, Hurwitz R, Moczall H, Lansmann S, Schuchman EH, Sandhoff K.
European Journal of Biochemistry 1997 Jan; 243(1-2):511.
Application:IP, Monkey, COS-1 cells.
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Cloning of a human acid sphingomyelinase cDNA with a new mutation that renders the enzyme inactive.
Ida H, Rennert OM, Eto Y, Chan WY.
Journal of Biochemistry 1993 Jul; 114(1):15.
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Human acid sphingomyelinase.
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