Immunoprecipation results using Western blot analysis. 293 cells were transfected with pSRa-VAV2 driving expression of human VAV2. SHD antiserum (Lane 1) or SHD-VAV2 antibody (Lane 2) were used to immunoprecipitate VAV2 from 300ug protein lysates. Each lane was loaded with 75 ug/mL the immunoprecipitated proteins.
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq