Glra1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot of rat spinal cord showing specific immunolabeling of the ~48k alpha1- and alpha2 subunits of the glycine receptor. The labeling was absent from a rat hippocampal (hipp) lysate as the glycine receptor is not expressed in the hippocampus.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of Glra1.
Immunogen
A synthetic peptide corresponding to N-terminus of rat Glra1.
Host
Rabbit
Theoretical MW (kDa)
48
Reactivity
Human, Mouse, Rat
Specificity
Specific for the ~48k Glra1 and Glra2 in Western blots of rat spinal cord and brain stem and in cell extracts.
Form
Lyophilized
Purification
Affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (Frozen sections) (1:1000)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 5 mM ammonium bicarbonate
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with PBS, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot of rat spinal cord showing specific immunolabeling of the ~48k alpha1- and alpha2 subunits of the glycine receptor. The labeling was absent from a rat hippocampal (hipp) lysate as the glycine receptor is not expressed in the hippocampus.Immunohistochemistry (Frozen sections)
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Gene Info — Glra1
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Publication Reference
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A highly conserved aspartic acid residue in the signature disulfide loop of the alpha 1 subunit is a determinant of gating in the glycine receptor.
Schofield CM, Jenkins A, Harrison NL.
The Journal of Biological Chemistry 2003 Jun; 278(36):34079.
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Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits.
Chatterton JE, Awobuluyi M, Premkumar LS, Takahashi H, Talantova M, Shin Y, Cui J, Tu S, Sevarino KA, Nakanishi N, Tong G, Lipton SA, Zhang D.
Nature 2002 Feb; 415(6873):793.
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Getting a bead on receptor movements.
Craig AM, Lichtman JW.
Nature Neuroscience 2001 Mar; 4(3):219.
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A highly conserved aspartic acid residue in the signature disulfide loop of the alpha 1 subunit is a determinant of gating in the glycine receptor.
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