DBH polyclonal antibody
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Specification
Product Description
Sheep polyclonal antibody raised against synthetic peptide of DBH.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus human DBH.
Host
Sheep
Theoretical MW (kDa)
75
Reactivity
Human, Primates
Form
Liquid
Purification
Affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot of human adrenal medulla lysate showing specific immunolabeling of the ~75k DBH protein. Using DBH polyclonal antibody (Cat # PAB9693). -
Gene Info — DBH
Entrez GeneID
1621Protein Accession#
P09172Gene Name
DBH
Gene Alias
DBM
Gene Description
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq
Other Designations
dopamine beta-hydroxylase
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Interactome
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Pathway
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Disease
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Publication Reference
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Striatal dopaminergic and serotonergic markers in human heroin users.
Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW.
Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 2001 May; 24(5):561.
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Stress-triggered activation of gene expression in catecholaminergic systems: dynamics of transcriptional events.
Sabban EL, Kvetnanský R.
Trends in Neurosciences 2001 Feb; 24(2):91.
Application:IHC, WB, Human, Mouse , Brains.
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Quantitation of tyrosine hydroxylase protein in the locus coeruleus from postmortem human brain.
Zhu M, Klimek V, Haycock JW, Ordway GA.
Journal of Neuroscience Methods 2000 Jun; 99(1-2):37.
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Striatal dopaminergic and serotonergic markers in human heroin users.
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