DBH polyclonal antibody
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Specification
Product Description
Sheep polyclonal antibody raised against synthetic peptide of DBH.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus human DBH.
Host
Sheep
Theoretical MW (kDa)
75
Reactivity
Human, Mouse, Primates
Form
Liquid
Purification
Affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot of human adrenal medulla lysate showing specific immunolabeling of the ~75k DBH protein. Using DBH polyclonal antibody (Cat # PAB9692). -
Gene Info — DBH
Entrez GeneID
1621Protein Accession#
P09172Gene Name
DBH
Gene Alias
DBM
Gene Description
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq
Other Designations
dopamine beta-hydroxylase
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Interactome
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Pathway
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Disease
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Publication Reference
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Striatal dopaminergic and serotonergic markers in human heroin users.
Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW.
Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 2001 May; 24(5):561.
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Stress-triggered activation of gene expression in catecholaminergic systems: dynamics of transcriptional events.
Sabban EL, Kvetnanský R.
Trends in Neurosciences 2001 Feb; 24(2):91.
Application:IHC, WB, Human, Mouse , Brains.
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Quantitation of tyrosine hydroxylase protein in the locus coeruleus from postmortem human brain.
Zhu M, Klimek V, Haycock JW, Ordway GA.
Journal of Neuroscience Methods 2000 Jun; 99(1-2):37.
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Striatal dopaminergic and serotonergic markers in human heroin users.
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