Gabrg2 (phospho S327) polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot of rat cortex showing specific immunolabeling of the ~45k Gabrg2 protein phosphorylated at Ser327 (Control, lane 1). Immunolabeling is blocked by the phospho-peptide (Peptide, lane 2) used as antigen, but not by the corresponding dephosphopeptide (not shown).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of Gabrg2.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S327 of rat Gabrg2.
Host
Rabbit
Theoretical MW (kDa)
45
Reactivity
Bovine, Chicken, Dog, Human, Mouse, Primates, Rat
Form
Liquid
Purification
Affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot of rat cortex showing specific immunolabeling of the ~45k Gabrg2 protein phosphorylated at Ser327 (Control, lane 1). Immunolabeling is blocked by the phospho-peptide (Peptide, lane 2) used as antigen, but not by the corresponding dephosphopeptide (not shown). -
Gene Info — Gabrg2
Entrez GeneID
29709Protein Accession#
P18508Gene Name
Gabrg2
Gene Alias
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Gene Description
gamma-aminobutyric acid (GABA) A receptor, gamma 2
Gene Ontology
HyperlinkGene Summary
O
Other Designations
gamma-aminobutyric acid A receptor, gamma 2|gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2|gamma-aminobutyric acid A receptor, gamma 2
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Publication Reference
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Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.
Qi ZH, Song M, Wallace MJ, Wang D, Newton PM, McMahon T, Chou WH, Zhang C, Shokat KM, Messing RO.
The Journal of Biological Chemistry 2007 Nov; 282(45):33052.
Application：WB, Mouse , HEK 293 cells, Mouse brain.
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Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit.
Ogris W, Poltl A, Hauer B, Ernst M, Oberto A, Wulff P, Hoger H, Wisden W, Sieghart W.
Biochemical Pharmacology 2004 Oct; 68(8):1621.
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Molecular and functional diversity of the expanding GABA-A receptor gene family.
Whiting PJ, Bonnert TP, McKernan RM, Farrar S, Le Bourdelles B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Thompson SA, Wafford KA.
Annals of the New York Academy of Sciences 1999 Apr; 868:645.
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Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.
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