Gabra1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot of mouse forebrain lysates from Wild Type (Control, lane 1) and Gabra1 knockout (Gabra1-K/O, lane 2) animals showing specific immunolabeling of the ~51 alpha1-subunit of the Gabra1. The labeling was absent from a lysate prepared from Gabra1 knockout animals.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of Gabra1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus rat Gabra1.
Host
Rabbit
Theoretical MW (kDa)
51
Reactivity
Bovine, Dog, Human, Mouse, Primates, Rat
Form
Liquid
Purification
Affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot of mouse forebrain lysates from Wild Type (Control, lane 1) and Gabra1 knockout (Gabra1-K/O, lane 2) animals showing specific immunolabeling of the ~51 alpha1-subunit of the Gabra1. The labeling was absent from a lysate prepared from Gabra1 knockout animals. -
Gene Info — Gabra1
Entrez GeneID
29705Protein Accession#
P62813Gene Name
Gabra1
Gene Alias
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Gene Description
gamma-aminobutyric acid (GABA) A receptor, alpha 1
Gene Ontology
HyperlinkGene Summary
O
Other Designations
gamma-aminobutyric acid A receptor, alpha 1|gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1|gamma-aminobutyric acid A receptor, alpha 1
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Publication Reference
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Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit.
Ogris W, Poltl A, Hauer B, Ernst M, Oberto A, Wulff P, Hoger H, Wisden W, Sieghart W.
Biochemical Pharmacology 2004 Oct; 68(8):1621.
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Subunit composition and quantitative importance of GABA(A) receptor subtypes in the cerebellum of mouse and rat.
Poltl A, Hauer B, Fuchs K, Tretter V, Sieghart W.
Journal of Neurochemistry 2003 Dec; 87(6):1444.
Application：IP, WB, Human, Mouse, Rat, HEK 293 cells, Mouse and Rat cerebellar extracts.
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Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.
McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, Howell O, Moore KW, Carling RW, Street LJ, Castro JL, Ragan CI, Dawson GR, Whiting PJ.
Nature Neuroscience 2000 Jun; 3(6):587.
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Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit.
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