Grm1/5 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of Grm1/Grm5.
Immunogen
A synthetic peptide corresponding to C-terminus rat Grm1/Grm5.
Host
Rabbit
Theoretical MW (kDa)
125, 250
Reactivity
Human, Mouse, Rat
Specificity
Specific for the ~125KDa monomer and the ~250KDa dimers of mGluR5 and mGluR1.
Form
Liquid
Purification
Affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (Frozen sections) (1:500)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Frozen sections)
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Gene Info — Grm1
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Gene Info — Grm5
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Publication Reference
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Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis.
Bhattacharya M, Babwah AV, Godin C, Anborgh PH, Dale LB, Poulter MO, Ferguson SS.
The Journal of Neuroscience 2004 Oct; 24(40):8752.
Application：IP, WB-Tr, Human, HEK 293 cells.
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The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region.
Francesconi W, Cammalleri M, Sanna PP.
Brain Research 2004 Oct; 1022(1-2):12.
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Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currents.
Blaabjerg M, Fang L, Zimmer J, Baskys A.
Experimental Neurology 2003 Oct; 183(2):573.
Application：Added, Recombinant protein.
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Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis.
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