ELK1 (phospho S383) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of ELK1.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S383 of human ELK1.
Host
Rabbit
Theoretical MW (kDa)
46
Reactivity
Dog, Human, Mouse, Primates, Rat, Zebra fish
Form
Liquid
Purification
Affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Recombinant protein)
Western blot of recombinant ELK1 showing specific immunolabeling of the ~46k ELK1 phosphorylated at Ser383 (Phos, lane 1). The immunolabeling is absent in dephospho-ELK1 (Non-Phos, lane 2). -
Gene Info — ELK1
Entrez GeneID
2002Protein Accession#
P19419Gene Name
ELK1
Gene Alias
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Gene Description
ELK1, member of ETS oncogene family
Omim ID
311040Gene Ontology
HyperlinkGene Summary
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
ELK1 protein|OTTHUMP00000023224|OTTHUMP00000023225
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Interactome
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Pathway
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Disease
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Publication Reference
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MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300.
Li QJ, Yang SH, Maeda Y, Sladek FM, Sharrocks AD, Martins-Green M.
The EMBO Journal 2003 Jan; 22(2):281.
Application:WB-Tr, Chicken, Embryo fibroblasts.
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Long-term depression in the adult hippocampus in vivo involves activation of extracellular signal-regulated kinase and phosphorylation of Elk-1.
Thiels E, Kanterewicz BI, Norman ED, Trzaskos JM, Klann E.
The Journal of Neuroscience 2002 Mar; 22(6):2054.
Application:WB-Ti, Rat, Hippocampus.
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Transcriptional regulation by extracellular signals: mechanisms and specificity.
Hill CS, Treisman R.
Cell 1995 Jan; 80(2):199.
Application:WB-Ce, WB-Tr, Human, Mammalian cells.
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MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300.
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