PARK2 (phospho S101) polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot of HEK293 cells transfected with PARK2 WT (Phospho) and PARK2 S101 mutant (non-phospho) showing the phospho-specific immunolabeling of the ~ 52 k parkin protein. The immunolabeling is absent in the PARK2 S101 mutant.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of PARK2.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S101 of human PARK2.
Host
Rabbit
Theoretical MW (kDa)
52
Reactivity
Bovine, Human, Primates
Form
Liquid
Purification
Affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Transfected lysate)
Western blot of HEK293 cells transfected with PARK2 WT (Phospho) and PARK2 S101 mutant (non-phospho) showing the phospho-specific immunolabeling of the ~ 52 k parkin protein. The immunolabeling is absent in the PARK2 S101 mutant. -
Gene Info — PARK2
Entrez GeneID
5071Protein Accession#
O60260Gene Name
PARK2
Gene Alias
AR-JP, LPRS2, PDJ, PRKN
Gene Description
Parkinson disease (autosomal recessive, juvenile) 2, parkin
Gene Ontology
HyperlinkGene Summary
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq
Other Designations
E3 ubiquitin ligase|OTTHUMP00000017565|OTTHUMP00000017566|OTTHUMP00000017567|parkin|parkin 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity.
Yamamoto A, Friedlein A, Imai Y, Takahashi R, Kahle PJ, Haass C.
The Journal of Biological Chemistry 2005 Feb; 280(5):3390.
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Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. The Royal Kings and Queens Parkinson's Disease Research Group.
Jenner P, Dexter DT, Sian J, Schapira AH, Marsden CD.
Annals of Neurology 1992 Jan; 32 Suppl:S82.
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Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity.
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