DDC polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DDC.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus human DDC.
Host
Rabbit
Theoretical MW (kDa)
55
Reactivity
Bovine, Dog, Guinea pig, Human, Rabbit, Rat, Sheep
Form
Liquid
Purification
Affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot of 5 ug of bovine adrenal medulla lysate showing specific immunolabeling of the ~55k DDC protein. Using DDC polyclonal antibody (Cat # PAB9598). -
Gene Info — DDC
Entrez GeneID
1644Protein Accession#
P20711Gene Name
DDC
Gene Alias
AADC
Gene Description
dopa decarboxylase (aromatic L-amino acid decarboxylase)
Gene Ontology
HyperlinkGene Summary
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq
Other Designations
L-Dopa decarboxylase|aromatic L-amino acid decarboxylase
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Interactome
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Pathway
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Disease
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Publication Reference
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Zonisamide Enhances Motor Effects of Levodopa, Not of Apomorphine, in a Rat Model of Parkinson's Disease.
Nishijima H, Miki Y, Ueno S, Tomiyama M.
Parkinson's Disease 2018 Dec; 2018:8626783.
Application:WB-Ti, Rat, Rat brains.
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Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum.
Haycock JW, Becker L, Ang L, Furukawa Y, Hornykiewicz O, Kish SJ.
Journal of Neurochemistry 2003 Nov; 87(3):574.
Application:ELISA, WB, Human, Human striatum.
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Lack of regulation of aromatic L-amino acid decarboxylase in intact bovine chromaffin cells.
Waymire JC, Haycock JW.
Journal of Neurochemistry 2002 May; 81(3):589.
Application:IP, WB, Bovine, Bovine adrenal medullary chromaffin cells.
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Striatal dopaminergic and serotonergic markers in human heroin users.
Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW.
Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 2001 May; 24(5):561.
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Zonisamide Enhances Motor Effects of Levodopa, Not of Apomorphine, in a Rat Model of Parkinson's Disease.
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