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Last updated: 2017/4/30
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TRB@ polyclonal antibody

  • Catalog # : PAB9052
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of TRB@.
  • Immunogen:
  • A synthetic peptide corresponding to residues surrounding amino acids 114 of human TRB@.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 34
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • This antibody recognizes 34 KDa TCR beta.
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western Blot (0.5-4 ug/mL)
    Immunohistochemistry (15-25 ug/mL)
    Immunoprecipitation (10-20 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (30% glycerol, 0.5% BSA, 0.01% thimerosal)
  • Storage Instruction:
  • Store at -20°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of TRB@ expression with Jurkat cell lysate.
  • Immunohistochemistry
  • Immunoprecipitation
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 6957
  • Gene Name:
  • TRB@
  • Gene Alias:
  • TCRB,TRB
  • Gene Description:
  • T cell receptor beta locus
  • Gene Summary:
  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq
  • Other Designations:
  • T-cell antigen receptor, beta polypeptide, T-cell receptor, beta cluster,T-cell receptor, beta cluster
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