MINPP1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MINPP1.
Immunogen
A synthetic peptide corresponding to amino acids 26-46 of human MINPP1.
Sequence
SLARCSLLEPRDPVASSLSPY
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.02% sodium azide
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
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Gene Info — MINPP1
Entrez GeneID
9562Gene Name
MINPP1
Gene Alias
DKFZp564L2016, HIPER1, MINPP2, MIPP
Gene Description
multiple inositol polyphosphate histidine phosphatase, 1
Gene Ontology
HyperlinkGene Summary
This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway
Other Designations
OTTHUMP00000020026|multiple inositol polyphosphate phosphatase 1|multiple inositol polyphosphate phosphatase 2
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Interactome
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Pathway
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Disease
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Publication Reference
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The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase.
Hidaka K, Kanematsu T, Caffrey JJ, Takeuchi H, Shears SB, Hirata M.
Experimental Cell Research 2003 Nov; 290(2):254.
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Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo.
Chi H, Yang X, Kingsley PD, O'Keefe RJ, Puzas JE, Rosier RN, Shears SB, Reynolds PR.
Molecular and Cellular Biology 2000 Sep; 20(17):6496.
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Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19.
Chi H, Tiller GE, Dasouki MJ, Romano PR, Wang J, O'keefe RJ, Puzas JE, Rosier RN, Reynolds PR.
Genomics 1999 Mar; 56(3):324.
Application:WB, Purified proteins.
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The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase.
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