INHA polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of INHA.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 18-23 of human INHA.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:20000)
Dot Blot (1:20000)
Western Blot (1:500)
Immunohistochemistry (1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.02% sodium azide
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot of INHA polyclonal antibody (Cat # PAB8965) with protein-coupled INHA samples. Antibody dilution at 1:500.Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
Dot Blot
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Gene Info — INHA
Entrez GeneID
3623Gene Name
INHA
Gene Alias
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Gene Description
inhibin, alpha
Omim ID
147380Gene Ontology
HyperlinkGene Summary
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. [provided by RefSeq
Other Designations
A-inhibin subunit|inhibin alpha subunit
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Interactome
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Disease
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Publication Reference
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Inhibin is more specific than calretinin as an immunohistochemical marker for differentiating sarcomatoid granulosa cell tumour of the ovary from other spindle cell neoplasms.
Shah VI, Freites ON, Maxwell P, McCluggage WG.
Journal of Clinical Pathology 2003 Mar; 56(3):221.
Application:IHC-P, Human, Human granulosa cell tumour.
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Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions.
Meunier H, Rivier C, Evans RM, Vale W.
PNAS 1988 Jan; 85(1):247.
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Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis.
Hsueh AJ, Dahl KD, Vaughan J, Tucker E, Rivier J, Bardin CW, Vale W.
PNAS 1987 Jul; 84(14):5082.
Application:AFC, RIA, Purified proteins.
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Inhibin is more specific than calretinin as an immunohistochemical marker for differentiating sarcomatoid granulosa cell tumour of the ovary from other spindle cell neoplasms.
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