CHN1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CHN1.
Immunogen
A synthetic peptide corresponding to amino acids 153-172 of human CHN1.
Sequence
REPAYKKHMPVLKETHDERD
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.02% sodium azide
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
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Gene Info — CHN1
Entrez GeneID
1123Gene Name
CHN1
Gene Alias
ARHGAP2, CHN, DURS2, RHOGAP2
Gene Description
chimerin (chimaerin) 1
Omim ID
118423Gene Ontology
HyperlinkGene Summary
This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular motor axon pathfinding. Heterozygous missense mutations in this gene cause Duane's retraction syndrome 2 (DURS2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
A-chimaerin|Chimerin 1 (GTPase-activating protein, rho, 2)|Rho GTPase-activating protein 2|a2-chimaerin|alpha-chimerin|n-chimerin
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Interactome
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Disease
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Publication Reference
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Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling.
Wang H, Yang C, Leskow FC, Sun J, Canagarajah B, Hurley JH, Kazanietz MG.
The EMBO Journal 2006 May; 25(10):2062.
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Cyclin' round the cell with Rac.
Ridley AJ.
Developmental Cell 2001 Aug; 1(2):160.
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Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling.
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