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Last updated: 2016/12/4
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POMC polyclonal antibody

  • Catalog # : PAB8938
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of POMC.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 138-176 of human POMC.
  • Sequence:
  • SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western Blot (1:1000)
    Immunoprecipitation (1:200)
    Immunohistochemistry (1:250)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In buffer containing 0.02% sodium azide
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunohistochemistry
  • Dot Blot
  • Application Image
  • Western Blot
  • Immunohistochemistry
  • Dot Blot
  • Gene Information
  • Entrez GeneID:
  • 5443
  • Gene Name:
  • POMC
  • Gene Alias:
  • ACTH,CLIP,LPH,MSH,NPP,POC
  • Gene Description:
  • proopiomelanocortin
  • Gene Summary:
  • This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000119991,adrenocorticotropic hormone,adrenocorticotropin,alpha-MSH,alpha-melanocyte-stimulating hormone,beta-LPH,beta-MSH,beta-endorphin,beta-melanocyte-stimulating hormone,corticotropin-like intermediary peptide,gamma-LPH,gamma-MSH,lipotropin b
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