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LRP5/LRP6 polyclonal antibody

  • Catalog # : PAB8812
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of LRP5/LRP6.
  • Immunogen:
  • A synthetic peptide corresponding to residues surrounding amino acids 437 of human LRP5, LRP6.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 170, 120
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • This antibody recognizes the ~170 KDa full length LRP-5/6 of human and mouse origins. A cleavage fragment (~120 KDa) can also be detected.
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western Blot (0.5-4 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (30% glycerol, 0.5% BSA, 0.01% thimerosal)
  • Storage Instruction:
  • Store at -20°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of LRP5/LRP6 with Jurkat cell lysate (Lane 1: 100 ug; Lane 2: 50 ug).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 4041
  • Gene Name:
  • LRP5
  • Gene Alias:
  • BMND1,EVR1,EVR4,HBM,LR3,LRP7,OPPG,OPS,OPTA1,VBCH2
  • Gene Description:
  • low density lipoprotein receptor-related protein 5
  • Other Designations:
  • exudative vitreoretinopathy 1,low density lipoprotein receptor-related protein 7,osteoporosis pseudoglioma syndrome
  • Gene Information
  • Entrez GeneID:
  • 4040
  • Gene Name:
  • LRP6
  • Gene Alias:
  • ADCAD2,FLJ90062,FLJ90421
  • Gene Description:
  • low density lipoprotein receptor-related protein 6
  • Gene Summary:
  • The LRP6 gene encodes a member of the low density lipoprotein receptor (LDLR) gene family, which consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDLR proteins are comprised of the same basic structural motifs: an extracellular domain that contains LDLR binding repeats and EGF repeats with associated spacer domains containing the YWTD motif; a single transmembrane-spanning domain; and a C-terminal cytoplasmic domain that generally contains at least 1 copy of the NPXY motif (Brown et al., 1998 [PubMed 9704021]). LRP6 and LRP5 (MIM 603506) function as coreceptors for WNT (MIM 164820) ligands and thus play a role in WNT signaling, which is important in a wide variety of biologic processes during pre- and postnatal life in invertebrates and vertebrates (Kokubu et al., 2004 [PubMed 15469977]).[supplied by OMIM
  • Other Designations:
  • low density lipoprotein-related protein 6
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