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Last updated: 2016/12/4
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LMNA polyclonal antibody

  • Catalog # : PAB8800
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of LMNA.
  • Immunogen:
  • A synthetic peptide corresponding to residues surrounding amino acids 220 of human LMNA.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 70
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • This antibody mainly detects full length (~70 KDa) and in a much lesser extent the cleaved fragments (45 KDa and 23 KDa) of Lamin A/C.
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western Blot (0.5-4 ug/mL)
    Immunohistochemistry (15-20 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (30% glycerol, 0.5 mg/mL BSA, 0.01% thimerosal)
  • Storage Instruction:
  • Store at -20°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Western Blot
  • Western blot analysis of LMNA in lysates from Jurkat cells (Lane 1 and 2) , mouse small intestine (Lane 3) and rat kidney (Lane 4) .
  • Immunohistochemistry
  • Application Image
  • Immunohistochemistry
  • Gene Information
  • Entrez GeneID:
  • 4000
  • Gene Name:
  • LMNA
  • Gene Alias:
  • CDCD1,CDDC,CMD1A,CMT2B1,EMD2,FPL,FPLD,HGPS,IDC,LDP1,LFP,LGMD1B,LMN1,LMNC,PRO1
  • Gene Description:
  • lamin A/C
  • Gene Summary:
  • The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq
  • Other Designations:
  • 70 kDa lamin,OTTHUMP00000015843,OTTHUMP00000015848
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