Western blot analysis of HDAC2 expression in lysates from Jurkat cells (lane 1) , mouse intestine (lane 2) and rat kidney (lane 3) . The antibody detects 55 kDa HDAC2 in samples from human, mouse, rat, chicken, hamster, and canine origins.
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events. [provided by RefSeq