Western blot analysis of HDAC10 expression. Lane 1: Jurkat Cells, Lane 2: Mouse Intestine, Lane 3: Rat Brain. The antibody recognizes 74 kDa HDAC-10 of human, mouse, and rat origins. 55 kDa cleavage fragment can also be detected in mouse and rat tissue lysates.
Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002 [PubMed 11677242]).[supplied by OMIM