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Last updated: 2016/12/4
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BRCA2 polyclonal antibody

  • Catalog # : PAB8596
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of BRCA2.
  • Immunogen:
  • A synthetic peptide corresponding to N-terminus of human BRCA2.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western Blot (0.5-4 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (30% glycerol, 0.5 mg/mL BSA, 0.01% thimerosal)
  • Storage Instruction:
  • Store at -20°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of BRCA2 expression in HeLa cell lysate.
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of BRCA2 polyclonal antibody (Cat # PAB8596) in NIH/3T3 cell lysate.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 675
  • Gene Name:
  • BRCA2
  • Gene Alias:
  • BRCC2,FACD,FAD,FAD1,FANCB,FANCD,FANCD1
  • Gene Description:
  • breast cancer 2, early onset
  • Gene Summary:
  • Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq
  • Other Designations:
  • BRCA1/BRCA2-containing complex, subunit 2,OTTHUMP00000018803,OTTHUMP00000042401,breast and ovarian cancer susceptibility gene, early onset,breast cancer 2 tumor suppressor,breast cancer susceptibility protein BRCA2
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