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Last updated: 2017/11/19
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PYCARD polyclonal antibody

  • Catalog # : PAB8553
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of PYCARD.
  • Immunogen:
  • A synthetic peptide corresponding to residues surrounding amino acids 185 of human PYCARD.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 25
  • Reactivity:
  • Human, Rat
  • Specificity:
  • The affinity purified antibody detects the 25 KDa human and rat ASC/TMS1. HL60 cell lysate can be used as a positive control.
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western Blot (0.5-4 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (30% glycerol, 0.5 mg/mL BSA, 0.01% thimerosal)
  • Storage Instruction:
  • Store at -20°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of PYCARD expression in HL-60 cell lysate.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Gene Name:
  • PYCARD
  • Gene Alias:
  • ASC,CARD5,MGC10332,TMS,TMS-1,TMS1
  • Gene Description:
  • PYD and CARD domain containing
  • Gene Summary:
  • This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • apoptosis-associated speck-like protein containing a CARD,caspase recruitment domain protein 5,target of methylation-induced silencing-1
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