HSD17B8 polyclonal antibody
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More Files
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Immunohistochemistry
Imunohistochemical analysis of human endometrium tissue, using HSD17B8 polyclonal antibody (Cat # PAB8493) .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HSD17B8.
Immunogen
A synthetic peptide corresponding to human HSD17B8.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2.0% Block Ace)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry
Imunohistochemical analysis of human endometrium tissue, using HSD17B8 polyclonal antibody (Cat # PAB8493) . -
Gene Info — HSD17B8
Entrez GeneID
7923Gene Name
HSD17B8
Gene Alias
D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9
Gene Description
hydroxysteroid (17-beta) dehydrogenase 8
Omim ID
601417Gene Ontology
HyperlinkGene Summary
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq
Other Designations
17-beta-HSD 8|17-beta-hydroxysteroid dehydrogenase 8|OTTHUMP00000029153|beta-ketoacyl-[acyl-carrier-protein] reductase-like|estradiol 17 beta-dehydrogenase 8|estrogen 17-oxidoreductase|short chain dehydrogenase/reductase family 30C, member 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Immature ovaries and polycystic kidneys in the congenital polycystic kidney mouse may be due to abnormal sex steroid metabolism.
Woo D, Lee GY, Anderson E, Aziz N.
Molecular and Cellular Endocrinology 2001 May; 176(1-2):155.
Application：IF, IHC-Fr, Mouse, Mouse reproductive tissues.
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Abnormal regulation of the Ke 6 gene, a new 17beta-hydroxysteroid dehydrogenase in the cpk mouse kidney.
Ramirez S, Fomitcheva I, Aziz N.
Molecular and Cellular Endocrinology 1998 Aug; 143(1-2):9.
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Immature ovaries and polycystic kidneys in the congenital polycystic kidney mouse may be due to abnormal sex steroid metabolism.
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