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Last updated: 2017/8/20
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MDC1 polyclonal antibody

  • Catalog # : PAB8487
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of MDC1.
  • Immunogen:
  • A synthetic peptide corresponding to human MDC1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western Blot (1-5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.1% proclin, 2.0% Block Ace)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of extract from 293T (lane 1) and HeLa cells (lane 2) , using MDC1 polyclonal antibody (Cat # PAB8487) .
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 9656
  • Gene Name:
  • MDC1
  • Gene Alias:
  • DKFZp781A0122,KIAA0170,MGC166888,NFBD1
  • Gene Description:
  • mediator of DNA damage checkpoint 1
  • Gene Summary:
  • The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000029090,homologue to Drosophila photoreceptor protein calphotin,nuclear factor with BRCT domains 1
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