APH1A polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of APH1A.
Immunogen
A synthetic peptide corresponding to human APH1A.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (3-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2.0% Block Ace)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western blot analysis of extract from Neuro 2a cells, using APH1A polyclonal antibody (Cat # PAB8483) . Lane 1: mock, lane 2: APH1A (247 a.a.) and lane 3: APH1A (265 a. a.) . -
Gene Info — APH1A
Entrez GeneID
51107Gene Name
APH1A
Gene Alias
6530402N02Rik, APH-1A, CGI-78
Gene Description
anterior pharynx defective 1 homolog A (C. elegans)
Omim ID
607629Gene Ontology
HyperlinkGene Summary
APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM
Other Designations
OTTHUMP00000014528|OTTHUMP00000014529|anterior pharynx defective 1 homolog A
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Interactome
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Pathway
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Disease
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Publication Reference
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The role of presenilin cofactors in the gamma-secretase complex.
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T.
Nature 2003 Mar; 422(6930):438.
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Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
Lee SF, Shah S, Li H, Yu C, Han W, Yu G.
The Journal of Biological Chemistry 2002 Nov; 277(47):45013.
Application:WB-Ti, Rat, Brain.
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Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling.
Fortini ME.
Nature Reviews. Molecular Cell Biology 2002 Sep; 3(9):673.
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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D.
Developmental Cell 2002 Jul; 3(1):85.
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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos.
Goutte C, Tsunozaki M, Hale VA, Priess JR.
PNAS 2002 Jan; 99(2):775.
Application:IEM, C. elegans, C. elegans embryos.
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The role of presenilin cofactors in the gamma-secretase complex.
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