MAPT polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of extract from rat brain homogenates (7 ug), using MAPT polyclonal antibody (Cat # PAB8481).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAPT.
Immunogen
A synthetic peptide corresponding to human MAPT.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (5-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2.0% Block Ace)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot analysis of extract from rat brain homogenates (7 ug), using MAPT polyclonal antibody (Cat # PAB8481). -
Gene Info — MAPT
Entrez GeneID
4137Gene Name
MAPT
Gene Alias
DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, TAU
Gene Description
microtubule-associated protein tau
Gene Ontology
HyperlinkGene Summary
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq
Other Designations
G protein beta1/gamma2 subunit-interacting factor 1|microtubule-associated protein tau, isoform 4
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Interactome
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Pathway
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Disease
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Publication Reference
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Phosphorylation of microtubule-associated protein tau by Ca2+/calmodulin-dependent protein kinase II in its tubulin binding sites.
Yamamoto H, Yamauchi E, Taniguchi H, Ono T, Miyamoto E.
Archives of Biochemistry and Biophysics 2002 Dec; 408(2):255.
Application：WB-Ti, Bovine, Brain.
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Ca2+- and calmodulin-dependent phosphorylation of microtubule-associated protein 2 and tau factor, and inhibition of microtubule assembly.
Yamamoto H, Fukunaga K, Tanaka E, Miyamoto E.
Biochemistry 1983 Oct; 41(4):1119.
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Phosphorylation of microtubule-associated protein tau by Ca2+/calmodulin-dependent protein kinase II in its tubulin binding sites.
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