Cubn polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of Cubn.
Immunogen
A synthetic peptide corresponding to rat Cubn.
Host
Rabbit
Reactivity
Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (2-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2.0% Block Ace)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot analysis of extract from rat heart (lane 1) , rat kidney (lane 2) and rat heart liver (lane3) , using Cubn polyclonal antibody (Cat # PAB8474) . -
Gene Info — Cubn
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Publication Reference
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Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule.
Christensen EI, Birn H.
American Journal of Physiology. Renal Physiology 2001 Apr; 280(4):F562.
Application:IHC, Dog, Rat, Kidney.
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Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1.
Aminoff M, Carter JE, Chadwick RB, Johnson C, Grasbeck R, Abdelaal MA, Broch H, Jenner LB, Verroust PJ, Moestrup SK, de la Chapelle A, Krahe R.
Nature Genetics 1999 Mar; 21(3):309.
Application:WB, Human, Human urine.
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The intrinsic factor-vitamin B12 receptor, cubilin, is assembled into trimers via a coiled-coil alpha-helix.
Lindblom A, Quadt N, Marsh T, Aeschlimann D, Morgelin M, Mann K, Maurer P, Paulsson M.
The Journal of Biological Chemistry 1999 Mar; 274(10):6374.
Application:IEM, IF, IHC-Fr, Rat, Kidneys, Small intestine.
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The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins.
Moestrup SK, Kozyraki R, Kristiansen M, Kaysen JH, Rasmussen HH, Brault D, Pontillon F, Goda FO, Christensen EI, Hammond TG, Verroust PJ.
The Journal of Biological Chemistry 1998 Feb; 273(9):5235.
Application:WB-Ti, Rabbit, Renal.
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Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule.
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