SIAH2 polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis of 293T cells overexpressing human SIAH2 with MG-132 (protease inhibitor) , using SIAH2 polyclonal antibody (Cat # PAB8469) .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SIAH2.
Immunogen
A synthetic peptide corresponding to human SIAH2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2.0% Block Ace)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Transfected lysate)
Western blot analysis of 293T cells overexpressing human SIAH2 with MG-132 (protease inhibitor) , using SIAH2 polyclonal antibody (Cat # PAB8469) . -
Gene Info — SIAH2
Entrez GeneID
6478Gene Name
SIAH2
Gene Alias
hSiah2
Gene Description
seven in absentia homolog 2 (Drosophila)
Omim ID
602213Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq
Other Designations
seven in absentia homolog 2
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Interactome
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Disease
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Publication Reference
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Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling.
Polekhina G, House CM, Traficante N, Mackay JP, Relaix F, Sassoon DA, Parker MW, Bowtell DD.
Nature Structural Biology 2002 Jan; 9(1):68.
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Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.
Hu G, Zhang S, Vidal M, Baer JL, Xu T, Fearon ER.
Genes & Development 1997 Oct; 11(20):2701.
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Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina).
Della NG, Senior PV, Bowtell DD.
Development 1993 Apr; 117(4):1333.
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Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling.
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