Western blot analysis of 293T cells overexpressing human SIAH1 with MG-132 (protease inhibitor) , using SIAH2 polyclonal antibody (Cat # PAB8468). Lane 1 : control. Lane 2 : SIAH1 gene transgenic cell treat with MG-132 (protease inhibitor).
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq
seven in absentia homolog 1,sonic hedgehog homolog