SLC3A2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SLC3A2.
Immunogen
A synthetic peptide corresponding to human SLC3A2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (50 ug/mL)
Western Blot (0.2-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2.0% Block Ace)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
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Gene Info — SLC3A2
Entrez GeneID
6520Gene Name
SLC3A2
Gene Alias
4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
Gene Description
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Omim ID
158070Gene Ontology
HyperlinkGene Summary
This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
4F2 cell-surface antigen heavy chain|4F2 heavy chain|CD98 heavy chain|antigen defined by monoclonal antibody 4F2, heavy chain|antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43|heavy chain|lymphocyte activation antigen 4F2 large subu
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Interactome
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Disease
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Publication Reference
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Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines.
Yanagida O, Kanai Y, Chairoungdua A, Kim DK, Segawa H, Nii T, Cha SH, Matsuo H, Fukushima J, Fukasawa Y, Tani Y, Taketani Y, Uchino H, Kim JY, Inatomi J, Okayasu I, Miyamoto K, Takeda E, Goya T, Endou H.
Biochimica et Biophysica Acta 2001 Oct; 1514(2):291.
Application:WB-Ce, Human, T24 cells.
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Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells.
Kim JY, Kanai Y, Chairoungdua A, Cha SH, Matsuo H, Kim DK, Inatomi J, Sawa H, Ida Y, Endou H.
Biochimica et Biophysica Acta 2001 Jun; 1512(2):335.
Application:WB-Ce, WB-Tr, Human, U87 cells.
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Expression of a system L neutral amino acid transporter at the blood-brain barrier.
Matsuo H, Tsukada S, Nakata T, Chairoungdua A, Kim DK, Cha SH, Inatomi J, Yorifuji H, Fukuda J, Endou H, Kanai Y.
Neuroreport 2000 Nov; 11(16):3507.
Application:IF, IHC, Rat, Brain.
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Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids.
Fukasawa Y, Segawa H, Kim JY, Chairoungdua A, Kim DK, Matsuo H, Cha SH, Endou H, Kanai Y.
The Journal of Biological Chemistry 2000 Mar; 275(13):9690.
Application:WB-Ti, Mouse, Brain.
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Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98).
Kanai Y, Segawa H, Miyamoto K, Uchino H, Takeda E, Endou H.
The Journal of Biological Chemistry 1998 Sep; 273(37):23629.
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Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines.
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