ZAP70 (phospho Y319) polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from SK-OV-3 cells using ZAP70 (phospho Y319) polyclonal antibody (Cat # PAB8197).
Immunofluorescence
Immunofluorescence staining of methanol-fixed HeLa cells using ZAP70 (phospho Y319) polyclonal antibody (Cat # PAB8197).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of ZAP70.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y319 of human ZAP70.
Host
Rabbit
Theoretical MW (kDa)
70
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Immunoaffinity purification
Concentration
1 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from SK-OV-3 cells using ZAP70 (phospho Y319) polyclonal antibody (Cat # PAB8197).Immunofluorescence
Immunofluorescence staining of methanol-fixed HeLa cells using ZAP70 (phospho Y319) polyclonal antibody (Cat # PAB8197). -
Gene Info — ZAP70
Entrez GeneID
7535Gene Name
ZAP70
Gene Alias
FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
Gene Description
zeta-chain (TCR) associated protein kinase 70kDa
Omim ID
176947Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq
Other Designations
syk-related tyrosine kinase|zeta-chain (TCR) associated protein kinase (70 kD)|zeta-chain associated protein kinase 70kDa|zeta-chain associated protein kinase, 70kD
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Interactome
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Disease
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