LEO1 (phospho S551) polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of LEO1.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S551 of human LEO1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
LEO1 (phospho S551) polyclonal antibody (Cat # PAB8172). Western blot analysis of LEO1 expression in Jurkat.Enzyme-linked Immunoabsorbent Assay
Dot Blot (Peptide)
Dot blot analysis of LEO1 (phospho S551) polyclonal antibody (Cat # PAB8172) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 ug/mL. -
Gene Info — LEO1
Entrez GeneID
123169Protein Accession#
Q8WVC0;NP_620147Gene Name
LEO1
Gene Alias
RDL
Gene Description
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Omim ID
610507Gene Ontology
HyperlinkGene Summary
LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM
Other Designations
Leo1, Paf1/RNA polymerase II complex component, homolog|replicative senescence downregulated leo1-like|senescence downregulated leo1-like
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Interactome
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Publication Reference
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Expression of the Leo1-like domain of replicative senescence down-regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts.
Zhao L, Tong T, Zhang Z.
FASEB Journal 2005 Apr; 19(6):521.
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Expression of the Leo1-like domain of replicative senescence down-regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts.
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