TSC1 (phospho S505) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of TSC1.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S505 of human TSC1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Peptide affinity purification
Recommend Usage
ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
Dot Blot (Peptide)
Dot blot analysis of TSC1 (phospho S505) polyclonal antibody (Cat # PAB8143) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 ug/mL. -
Gene Info — TSC1
Entrez GeneID
7248Protein Accession#
NP_000359;Q92574Gene Name
TSC1
Gene Alias
KIAA0243, LAM, MGC86987, TSC
Gene Description
tuberous sclerosis 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000022439|hamartin|tuberous sclerosis 1 protein|tumor suppressor
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Interactome
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Pathway
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Disease
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Publication Reference
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Hamartin and tuberin immunohistochemical expression in cutaneous fibroepithelial polyps.
Wu J, Khalil FK, Keehn CA, Saeed S, Morgan MB.
Journal of Cutaneous Pathology 2004 May; 31(5):383.
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Genotype and psychological phenotype in tuberous sclerosis.
Lewis JC, Thomas HV, Murphy KC, Sampson JR.
Journal of Medical Genetics 2004 Mar; 41(3):203.
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Tuberin and hamartin expression is reduced in the majority of subependymal giant cell astrocytomas in tuberous sclerosis complex consistent with a two-hit model of pathogenesis.
Jozwiak S, Kwiatkowski D, Kotulska K, Larysz-Brysz M, Lewin-Kowalik J, Grajkowska W, Roszkowski M.
Journal of Child Neurology 2004 Feb; 19(2):102.
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Hamartin and tuberin immunohistochemical expression in cutaneous fibroepithelial polyps.
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