PIK3CD (phospho Y524) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of PIK3CD.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y524 of human PIK3CD.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Peptide affinity purification
Recommend Usage
ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
Dot Blot (Peptide)
Dot blot analysis of PIK3CD (phospho Y524) polyclonal antibody (Cat # PAB8136) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 ug/mL. -
Gene Info — PIK3CD
Entrez GeneID
5293Protein Accession#
NP_005017;O00329Gene Name
PIK3CD
Gene Alias
p110D
Gene Description
phosphoinositide-3-kinase, catalytic, delta polypeptide
Omim ID
602839Gene Ontology
HyperlinkGene Summary
Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. See MIM 602838. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha (MIM 171834), p110-beta (MIM 602925), and p110-gamma (MIM 601232). p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins (see MIM 171833) and with GTP-bound Ras.[supplied by OMIM
Other Designations
OTTHUMP00000001595|phosphatidylinositol 3-kinase, catalytic, delta polypeptide|phosphoinositide-3-kinase C
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Interactome
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Disease
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Publication Reference
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Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.
Khan NA, Di Cello F, Nath A, Kim KS.
Journal of Neurovirology 2003 Dec; 9(6):584.
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Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement.
Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE.
Journal of Immunology 2003 Mar; 170(5):2647.
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HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.
Deregibus MC, Cantaluppi V, Doublier S, Brizzi MF, Deambrosis I, Albini A, Camussi G.
The Journal of Biological Chemistry 2002 May; 277(28):25195.
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Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.
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