TSC2 (phospho S664) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of TSC2.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S664 of human TSC2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
Dot Blot (Peptide)
Dot blot analysis of TSC2 (phospho S664) polyclonal antibody (Cat # PAB8108) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 ug/mL. -
Gene Info — TSC2
Entrez GeneID
7249Protein Accession#
NP_000539;P49815Gene Name
TSC2
Gene Alias
FLJ43106, LAM, TSC4
Gene Description
tuberous sclerosis 2
Gene Ontology
HyperlinkGene Summary
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
tuberin
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Interactome
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Pathway
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Disease
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Publication Reference
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Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
Li Y, Inoki K, Guan KL.
Molecular and Cellular Biology 2004 Sep; 24(18):7965.
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Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.
Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL.
Genes & Development 2004 Jul; 18(13):1533.
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Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.
Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP.
The Journal of Biological Chemistry 2004 May; 279(29):29930.
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Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
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