NFATC2 (phospho S330) polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of NFATC2.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S330 of human NFATC2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Enzyme-linked Immunoabsorbent Assay
Dot Blot (Peptide)
Dot blot analysis of NFATC2 (phospho S330) polyclonal antibody (Cat # PAB8105) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 ug/mL. -
Gene Info — NFATC2
Entrez GeneID
4773Protein Accession#
NP_036472Gene Name
NFATC2
Gene Alias
KIAA0611, NFAT1, NFATP
Gene Description
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Omim ID
600490Gene Ontology
HyperlinkGene Summary
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
NFAT pre-existing subunit|NFAT transcription complex, preexisting component|OTTHUMP00000031291|T cell transcription factor NFAT1|nuclear factor of activated T-cells, cytoplasmic 2|nuclear factor of activated T-cells, preexisting component|preexisting nucl
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation.
Golks A, Tran TT, Goetschy JF, Guerini D.
The EMBO Journal 2007 Oct; 26(20):4368.
-
Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter.
Gibson HM, Hedgcock CJ, Aufiero BM, Wilson AJ, Hafner MS, Tsokos GC, Wong HK.
Journal of Immunology 2007 Sep; 179(6):3831.
-
Structure-function analysis of the WIP role in T cell receptor-stimulated NFAT activation: evidence that WIP-WASP dissociation is not required and that the WIP NH2 terminus is inhibitory.
Dong X, Patino-Lopez G, Candotti F, Shaw S.
The Journal of Biological Chemistry 2007 Oct; 282(41):30303.
-
Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com