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Last updated: 2016/10/23
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MAP3K8 (phospho T290) polyclonal antibody

  • Catalog # : PAB8091
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAP3K8.
  • Immunogen:
  • Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T290 of human MAP3K8.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A purification
  • Recommend Usage:
  • ELISA (1:1000)
    Dot Blot (1:500)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Dot Blot (Peptide)
  • Dot Blot (Peptide)
  • Dot blot analysis of MAP3K8 (phospho T290) polyclonal antibody (Cat # PAB8091) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 ug/mL.
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 1326
  • Protein Accession#:
  • P41279;NP_005195
  • Gene Name:
  • MAP3K8
  • Gene Alias:
  • COT,EST,ESTF,FLJ10486,TPL2,Tpl-2,c-COT
  • Gene Description:
  • mitogen-activated protein kinase kinase kinase 8
  • Gene Summary:
  • This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. [provided by RefSeq
  • Other Designations:
  • Cancer Osaka thyroid oncogene,Ewing sarcoma transformant,OTTHUMP00000019392,OTTHUMP00000019393,cot (cancer Osaka thyroid) oncogene,proto-oncogene serine/threoine protein kinase,tumor progression locus-2
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